The Ford E-350 comes with a standard 255-hp 5.4-liter Triton V8 mated to a four-speed automatic transmission. There are two optional engines available, with both being paired to a TorqShift five-speed automatic transmission. A 305-hp 6.8-liter Triton V10 or a 235-hp 6.0-liter Powerstroke diesel with 440 lb.-ft. of torque. Standard features include four-wheel anti-lock disc brakes, underbody full-size spare, air conditioning, tilt steering wheel and variable intermittent wipers. The E-350 is available in the regular or in the extended length version. The cargo van offers both a commercial and a recreational trim. The passenger wagon which has standard traction and stability control with roll-over mitigation offers a rugged XL trim or a well equipped XLT trim and can accommodate up to 15 passengers. All wagons and recreational vans are standard with AdvanceTrac w/Roll Stability Control, this safety feature is optional on commercial vans.
For 2010, the aero mirrors now have convex spotters, SYNC and satellite radio are now available, and illuminated vanity mirrors have been removed from the recreational vans.